b-raf inhibitor 1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2074	Raf inhibitor 1	B-Raf inhibitor 1	Raf
	B-Raf inhibitor 1 (B-Raf inhibitor 1) is a potent and selective B-Raf inhibitor.		Raf
T4167	Raf inhibitor 1 dihydrochloride	B-Raf inhibitor 1 dihydrochloride	Raf
	Raf inhibitor 1 dihydrochloride (B-Raf inhibitor 1 dihydrochloride) is a potent and selective B-Raf inhibitor.		Raf
T1845	B-Raf IN 1		Raf
	B-Raf IN 1 is a B-Raf (IC50: 24 nM) and c-Raf (IC50: 25 nM) inhibitor.		Raf
T2473	PLX-4720	PLX4720	Raf
	PLX-4720 is a potent and selective inhibitor of B-Raf (V600E) (IC50: 13 nM), equally potent to c-Raf-1(Y340D and Y341D mutations).		Raf
T1792L	Regorafenib monohydrate		Raf , VEGFR , c-RET , PDGFR , c-Kit , Autophagy
	Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine VEGFR3, PDGFR-β, KIT, RET, RAF-1, B-RAF and B-RAF(V600E) respect...		Raf , VEGFR , c-RET , PDGFR , c-Kit , Autophagy
T6882	LY3009120	DP-4978	Raf , Autophagy
	LY3009120 (DP-4978) is a potent pan-Raf inhibitor with IC50 of 44 nM, 31-47 nM, and 42 nM for A-raf, B-Raf, and C-Raf in A375 cells, respectively. Phase 1.		Raf , Autophagy
T6318	AZ 628		Apoptosis , Raf
	AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc.		Apoptosis , Raf
T2382	Vemurafenib	RO5185426,RG7204,PLX4032	Raf , MAPK , ACK , Src , Autophagy
	Vemurafenib (RG7204) is a B-RAF inhibitor that inhibits RAFV600E and c-RAF-1 (IC50=31/48 nM) selectively and potently. Vemurafenib exhibits antitumor activity and is used for the treatment of BRAF V600E mutation-positive...		Raf , MAPK , ACK , Src , Autophagy
T16909	Sorafenib-d3	Sorafenib (D3),Bay 43-9006 (D3)	Raf , VEGFR
	Sorafenib-d3 (Bay 43-9006 (D3)) is a deuterium-labeled Sorafenib which is a multikinase inhibitor(IC50s: 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively).		Raf , VEGFR
T0093	Sorafenib tosylate	Bay 43-9006	Apoptosis , Raf , VEGFR , FLT , Ferroptosis , PDGFR , c-Kit , Autophagy
	Sorafenib tosylate (Bay 43-9006) is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).
T0093L	Sorafenib	Bay 43-9006	Apoptosis , Raf , VEGFR , FLT , Ferroptosis , PDGFR , c-Kit , Autophagy
	Sorafenib (Bay 43-9006) is a multikinase inhibitor that inhibits Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, FLT3, c-Kit, and others (IC50=6/22/90/15/20/20/57/58 nM) with oral activity. Sorafenib has antitumor activity...
T38511	AWL-II-38.3		Ephrin Receptor
	AWL-II-38.3 is a highly effective inhibitor of EphA3, a receptor for ephrin-A. It demonstrates potent kinase inhibitory activity against EphA3 and does not show significant cellular activity against Src-family kinases or...		Ephrin Receptor
T6277	Doramapimod	BIRB 796	Raf , p38 MAPK , Autophagy
	Doramapimod (BIRB 796) is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but weakly inhibits c-RAF, Fyn, Lck, ERK-1, SYK, IKK2, and ZAP-70.		Raf , p38 MAPK , Autophagy
T22341	GSK-114		Others
	GSK-114, a selective inhibitor of TNNI3 Interacting Kinase (TNNI3K) with IC50 of 25 nM, shows significant bias for TNNI3K over B-Raf with IC50 of 1000 nM, exceptional broad spectrum kinase selectivity and adequate oral e...		Others
T15480	HG6-64-1	HMSL 10017-101-1	Others
	HG6-64-1 is a potent and selective inhibitor of B-Raf (IC50: 0.09 μM on B-raf V600E transformed Ba/F3 cells).		Others
T12685	RAF mutant-IN-1		Others
	RAF mutant-IN-1 is an inhibitor of RAF kinase(IC50 values of 21 nM, 30 nM and 392 nM for C-RAF 340D/Y341D, B-RAFV600E and B-RAFWT, respectively).		Others
T79813	Raf inhibitor 3		Raf
	Raf inhibitor 3 (Example 30), a potent inhibitor of both B-Raf and C-Raf, exhibits IC50 values below 15 nM. It is applicable in cancer research studies [1].		Raf
T60727	B-Raf IN 8
	B-Raf IN 8 (compound 7g) is a potent inhibitor of B-Raf (IC 50 = 70.65 nM). B-Raf IN 8 shows antitumor activity which has IC 50 values of 9.78, 13.78, 18.52 and 29.85 μM against hepatocellular carcinoma (HEPG-2), colon ...
T12976	Sorafenib-d4	Sorafenib (D4),Bay 43-9006 (D4)	Others
	Sorafenib D4 is the deuterium labeled Sorafenib. Sorafenib is an inhibitor of multikinase (Raf-1, B-Raf, and VEGFR-3 IC50s of 6 nM, 20 nM, and 22 nM, respectively).		Others
T60933	B-Raf IN 7
	B-Raf IN 7 (compound 6a) is a potent inhibitor of B-Raf with an IC 50 of 110.23 nM. B-Raf IN 7 has antitumor activity against colon carcinoma cells(HCT-116), mammary gland cells(MCF-7), hepatocellular carcinoma cells(HEP...